I recently graduated in medicine from Townsville, Australia, and I still enjoy writing blogs on medicine and pharmacy-related topics. I appreciate writing about my experience on different placements or topics I'm interested in. As English is my second language, writing blogs is a hobby and a fun challenge!
All tagged Aqueous cream
I have made a guide on how to do an assessment and a comparative study on the release of an API in three chosen topical semisolid dosage form. I used the USP Dissolution Apparatus 2 and aspirin as my API. The purpose of this pharmaceutic exercise was to introduce us on how to use the dissolution methods and understand its relevance.
Appendix of the project with all the tables that did not feature throughout the presenting project. Includes: amount of CBP (grams) used and the surface area utilised (cm2) for each formulation and days, textural profiling for each formulation and dissolution results of all the formulations at day 0, 7, 14, 28 and 60.
The effect of diluting the formulations and the standard formulation containing Dovate® with aqueous cream and homogenizing in a pharmacy setting showed that it was a major factor of slowing down or restricting the release CBP.
A t-test for spreadability was carried out for each formulation and compared to the standard. A dependent t-test, due to being in the same sample, will be used.
The collecting of the results expanded over a 28-day period where 4 dissolutions curves were made. On Day 60 the last dissolution curve was made to expand on the degradation studies.
In analytical chemistry the accurate quantitative measurement of the composition of samples, such as in spectroscopy, would require a calibration using standard samples of known composition. A calibration curve is an analytical method to determine the concentration of an unknown sample solution.
When an active pharmaceutical ingredient (API) is incorporated into a formulation, a rate of release of that API occurs. This is the case with a variety of formulations. Clobetasol and various surfactants that were incorporated into aqueous cream during this experiment followed this concept.
Topical corticosteroids are formulated for the treatment of dermatoses. These types of formulations vary in efficacy due to the factors on which such efficacy is dependent. Within a pharmacy setting, manufacturing methods are simplified. Do these affect its integrity?
During my final year of my bachelor of pharmacy I had the joy of doing a project in pharmaceutics on topical corticosteroids. This project took us 6 months to accomplish and it mainly taught us about research, reading the literature and to attempt at making a pharmaceutics project.
